Abstract Methylglyoxal bis (3-aminopropyl-amidinohydrazone)(MGBA), methylglyoxal bis (4- aminobutyl-amidinohydrazone)(MGBT), methylglyoxal bis (cyclohexyl-amidinohydrazone)( MGBC) and methylglyoxal bis (butyl-amidinohydrazone)(MGBB) were synthesized as potent competitive inhibitors for polyamine biosynthetic enzymes. Four compounds competitively inhibited S-adenosylmethionine decarboxylase. Ornithine decarboxylase was also ...
