Recent years have seen the emergence of 4-amino-3,5-dihalopyridines as an important structural motif in medicinal chemistry; for example, as intermediates, which can be further functionalised through cross-coupling reactions 1 and as pharmaceutically active compounds across a range of disease areas. 2, 2a, 2b, 2c, 2d and 2e Approaches to these structures often commence with 4-amino-3,5-dichloropyridine and incorporate further functionality through ...
