Amino Acids 2005-06-01

Synthesis, characteristics and biological activity of pentacoordinated spirophosphoranes derived from amino acids.

L Yu, Z Liu, H Fang, Q L Zeng, Y F Zhao

Index: Amino Acids 28(4) , 369-72, (2005)

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Abstract

The reactions of phosphorus trichloride with various amino acids afford the pentacoordinated spirophosphoranes. The reaction procedures were traced by (31)P NMR spectra techniques. A new crystal structure of alanine derivative was characterized, which is a slightly distorted TBP structure. Besides, this kind of spirophosphoranes are potent inhibitors to tyrosinase.