Efficient Synthesis of Naphtho [1, 2-e][1, 3] oxazine derivatives via a chemoselective reaction with the aid of low-valent titanium reagent

D Shi, S Rong, G Dou, M Wang

Index: Shi, Daqing; Rong, Shaofeng; Dou, Guolan; Wang, Manman Journal of Combinatorial Chemistry, 2010 , vol. 12, # 1 p. 25 - 30

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Citation Number: 14

Abstract

A series of new naphtho [1, 2-e][1, 3] oxazine derivatives such as trans-1, 3-diaryl-1 H- naphtho [1, 2-e][1, 3] oxazine-2 (3 H)-carbonyl chloride, 1-aryl-2-benzyl-1, 2-dihydronaphtho [1, 2-e][1, 3] oxazine-3-one, and trans-1, 3-diaryl-1 H-naphtho [1, 2-e][1, 3] oxazine-2 (3 H)- carbaldehyde were selectively synthesized via a chemoselective reaction of 1, 3-diaryl-2, 3- dihydro-1 H-naphtho [1, 2-e][1, 3] oxazines and triphosgene or triethyl orthoformate, ...