Analytical and Bioanalytical Chemistry 2006-09-01

Gas chromatography-electron capture detection determination of Dacthal and its di-acid metabolite in soil after ultrasound-assisted extraction and in situ focused microwave-assisted derivatization.

A Caballo-López, M D Luque de Castro

Index: Anal. Bioanal. Chem 386(2) , 341-5, (2006)

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Abstract

A quantitative method for the determination of Dacthal and its di-acid metabolite in soil has been developed by coupling ultrasound-assisted extraction and microwave-assisted derivatization of the analytes prior to gas chromatography-electron capture detection for individual separation and measurement. The main factors affecting both extraction efficiency and derivatization were optimized by experimental design methodology. The proposed approach allows extraction of these pollutants from spiked sediment and soil with efficiencies similar to those provided by the reference method but with a drastic reduction of both the extraction and derivatization times. The repeatability of the analyses, expressed as RSD, of Dacthal and its di-acid metabolite was 4.6% and 5.4%, respectively; meanwhile, the RSD for within-laboratory reproducibility was 8.7% and 9.2%, respectively.