Chemical Communications 2009-11-28

Lewis base-catalyzed three-component Strecker reaction on water. An efficient manifold for the direct alpha-cyanoamination of ketones and aldehydes.

Fabio Cruz-Acosta, Alicia Santos-Expósito, Pedro de Armas, Fernando García-Tellado

Index: Chem. Commun. (Camb.) (44) , 6839-41, (2009)

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Abstract

The first three-component organocatalyzed Strecker reaction operating on water has been developed. The manifold utilizes ketones (aldehydes) as the starting carbonyl component, aniline as the primary amine, acetyl cyanide as the cyanide source and N,N-dimethylcyclohexylamine as the catalyst.