Molecular Diversity 2011-08-01

Discovery of a β-glucosidase inhibitor from a chemically engineered extract prepared through sulfonylation.

Mario O Salazar, Oscar Micheloni, Andrea M Escalante, Ricardo L E Furlan

Index: Mol. Divers. 15(3) , 713-9, (2011)

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Abstract

A semisynthetic β-glucosidase inhibitor was identified from a chemically engineered extract prepared by reaction with benzenesulfonyl chloride. The structure includes a natural histamine portion and a benzenesulfonyl portion introduced during the diversification step.