Bioscience, Biotechnology, and Biochemistry 2002-02-01

Kinetic resolutions of indan derivatives using bacteria.

Naoki Tarui, Hayao Watanabe, Kohji Fukatsu, Shigenori Ohkawa, Kazuo Nakahama

Index: Biosci. Biotechnol. Biochem. 66(2) , 464-6, (2002)

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Abstract

Racemic indan derivatives have been resolved by the hydrolysis of amide bonds using Corynebacterium ammoniagenes IFO12612 to produce (S)-amine and (R)-amides. In the kinetic resolution of 1 (N-12-(6-methoxy-indan-1-yl)ethyl]acetamide), it was possible to run the reaction to 44% conversion on a 10-g scale, obtaining (S)-amine 4 ((S)-2-(6-methoxy-indan-1-yl)ethylamine) at >99% enantiomeric excess (ee) and (R)-1 at 98% ee.