Pakistan journal of pharmaceutical sciences 2013-05-01

Synthesis and cytotoxic activity of some derivatives of alkyl piperidine.

Sarwat Jahan, Shamim Akhtar, Zafar Saied Saify, Nousheen Mushtaq, Ali Akbar Sial, Arfa Kamil, Muhammed Arif

Index: Pak. J. Pharm. Sci. 26(3) , 517-23, (2013)

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Abstract

Synthesis of novel phenacyl derivatives of alkyl piperidine as cytotoxic agents via simple and single step reaction procedure is going to be reported here. Twelve new compounds were successfully synthesized in moderate yield and in solid form. Their synthesis was confirmed by TLC, melting point, CHN analysis and through different spectral studies such as UV, IR, Mass and proton NMR. The advantages of this synthetic route are simple operation, mild reaction conditions and good yields. These newly synthesized derivatives were extensively explored for their cytotoxicity by brine shrimp lethality assay.