Clinical Chemistry 1991-08-01

Characterization of sodium-selective optode membranes based on neutral ionophores and assay of sodium in plasma.

K Seiler, K Wang, E Bakker, W E Morf, B Rusterholz, U E Spichiger, W Simon

Index: Clin. Chem. 36(8) , 1350-1355, (1991)

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Abstract

Plasticized poly(vinyl chloride) membranes that incorporate a highly lipophilic sodium-selective neutral ionophore (ETH 4120) and novel H(+)-selective chromo-ionophores, lipophilic isologs of Nile Blue, are used in the competitive binding of Na+ and H+ for a reversible, optical determination of sodium activities in buffered solutions at different selected pH values. These optode membranes are used to assay total sodium concentrations in pH-buffered human blood plasma.