Molecules 2013-01-01

Synthesis and in vitro antiproliferative activity of new phenylaminoisoquinolinequinones against cancer cell lines.

Virginia Delgado, Andrea Ibacache, Verónica Arancibia, Cristina Theoduloz, Jaime A Valderrama

Index: Molecules 18(1) , 721-34, (2013)

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Abstract

A variety of phenylaminoisoquinolinequinones were synthesized and tested for their antiproliferative activity against three human-tumor derived cancer cell lines. The new aminoquinones were prepared from 4-methoxycarbonyl-3-methylisoquinoline-5,8-quinone (1) via acid-induced amination and bromination reactions. Remarkable differences in antiproliferative activity were observed depending upon the location and donor capacity of the substituted phenylamino group at the quinone nucleus. The effect of the substituents on the biological activity is discussed in terms of the donor-acceptor interactions which were evaluated through the redox properties of the aminoquinones.