ACS Combinatorial Science 2012-03-12

Visual monitoring of solid-phase extraction using chromogenic fluorous synthesis supports.

Christopher Blackburn

Index: ACS Comb. Sci. 14(3) , 150-4, (2012)

Full Text: HTML

Abstract

Reductive aminations and further transformations of an azo dye and fluorous tagged aldehyde are described. The intensely colored 2,4-dialkoxybenzyl protected amines undergo Fmoc-based peptide coupling, Suzuki reactions, and sulfonamide formation with product isolation facilitated by visual monitoring of fluorous solid phase extraction. Target compounds are released from the supports in high yields and purities by treatment with trifluoroacetic acid (TFA).