Organic Letters 2008-12-18

In situ "click" assembly of small molecule matrix metalloprotease inhibitors containing zinc-chelating groups.

Mingyu Hu, Junqi Li, Shao Q Yao

Index: Org. Lett. 10(2) , 5529-5531, (2008)

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Abstract

A panel of small molecule-based MMP inhibitors containing rhodanine warheads was assembled using "one-pot" click chemistry. Upon biological screening, moderate inhibitors were identified which specifically targets MMP-7 and MMP-13 over other MMPs.