Phosphonic acid and phosphinic acid tripeptides as inhibitors of glutathionylspermidine synthetase

C Verbruggen, S De Craecker, P Rajan, XY Jiao…

Index: Verbruggen, Christophe; De Craecker, Sofie; Rajan, Padinchare; Jiao, Xian-Yun; Borloo, Marianne; Smith, Keith; Fairlamb, Alan H.; Haemers, Achiel Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 3 p. 253 - 258

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Citation Number: 40

Abstract

A series of phosphonic and phosphinic acid derivatives of glutathione were synthesized as potential inhibitors of glutathionylspermidine synthetase, an essential enzyme in the biosynthesis of trypanothione in trypanosomatids. The compounds showed moderate activity.