Tetrahedron Letters

Palladium-catalyzed reaction of aryl halides with ureas

GA Artamkina, AG Sergeev, IP Beletskaya

Index: Artamkina, Galina A.; Sergeev, Alexey G.; Beletskaya, Irina P. Tetrahedron Letters, 2001 , vol. 42, # 26 p. 4381 - 4384

Full Text: HTML

Citation Number: 95

Abstract

A new method for the palladium-catalyzed arylation of ureas is described. The coupling reaction of urea and phenylurea with aryl halides containing electron-withdrawing groups in the p-position in dioxane in the presence of 0.5–1.0 mol% of Pd2dba3· CHCl3, Xantphos and Cs2CO3 as a base gives N, N′-diarylureas in yields of 64–92%.