A number of studies have been made on the biologically unique properties of trifluoromethylated organic compounds,1) and several synthetic methods for these compounds have been developed in recent years. Reported indirect routes involve, 1. a halogen-exchange of CCl3 with HF-SbCl5,2) and 2. fluorination of CO2H by SF4,3) as practical methods. Meanwhile, a direct route for the introduction of a perfluoroalkyl group into an aromatic ring by the ...
