Chemical Communications 2012-11-04

Polymorphism and tautomeric preference in fenobam and the utility of NLO response to detect polymorphic impurities.

Sajesh P Thomas, K Nagarajan, T N Guru Row

Index: Chem. Commun. (Camb.) 48(85) , 10559-61, (2012)

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Abstract

Crystal structures of polymorphs and solvatomorphs of the potential anxiolytic drug fenobam exhibit an exclusive preference for one of the two possible tautomeric structures. A novel methodology based on nonlinear optical response has been successfully employed to detect the presence of a polymorphic impurity in a mixture of polymorphs.