Synthesis, enzymatic evaluation, and docking studies of fluorogenic caspase 8 tetrapeptide substrates

P Reszka, R Schulz, K Methling, M Lalk…

Index: ChemMedChem, , vol. 5, # 1 p. 103 - 117

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Citation Number: 10

Abstract

... ChemMedChem, 5: 103–117. ... Volume: Issue: Page: ... selective for caspase 8 over caspase 3 (Table 3). The 10-fold higher K M values for caspase 3 relative to caspase 8 are reflected in the lower binding energy for the productive conformation, ranging between 2 and 5 kcal mol ...