Journal of Combinatorial Chemistry 2009-01-01

New one-pot four-component synthesis of disubstituted pyrido[2,3-d]pyrimidine-6-carboxamide derivatives.

Ahmad Shaabani, Mozhdeh Seyyedhamzeh, Ali Maleki, Fahimeh Rezazadeh, Maryam Behnam

Index: J. Comb. Chem. 11(3) , 375-7, (2009)

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Abstract

In this work, 1,2,3,4,5,8-hexahydro-1,3,7-trimethyl-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide derivatives were synthesized in a simple and efficient method from the four-component condensation reaction of diketene, an aliphatic or aromatic amine, an aromatic aldehyde, and 6-amino-1,3-dimethyluracil in the presence of a catalytic amount of p-toluenesulfonic acid under mild conditions at ambient temperature in high yields.