1-Trifluoromethyl-1, 2, 2-triphenylethylenes. Synthesis and postcoital antifertility activity

WJ Middleton, D Metzger…

Index: Middleton,W.J. et al. Journal of Medicinal Chemistry, 1971 , vol. 14, p. 1193 - 1197

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Citation Number: 26

Abstract

The (trifluoromethy1) triphenylethylenes show a surprising chemical stability, with no isomerization occurring when they are treated with aq acids or bases. Honever, they are easily reduced to the ethane, even hy mild reducing agents such as aq HI. Pharmaco1qgy.- Postcoital antifertility and uterotrophic activities in the rat were determined using a method developed by Strauss. 8 Immature female Holtzmnn rats (28 days old) were induced into ...

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