Nucleosides, Nucleotides & Nucleic Acids 2001-01-01

Synthesis and biological evaluation of pyridin-2-one nucleosides.

C M Huntley, A S Cotterill, J Y Maillard, J Balzarini, C Simons

Index: Nucleosides Nucleotides 20 , 731-733, (2001)

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Abstract

The synthesis of 1-(beta-D-ribofuranosyl)pyridin-2-one-3-carboxylic acid and the 3-carboxamide as well as a short series of 3N-carboxamides, prepared by TPTU/HOBt coupling of primary amines with 1-(beta-D-ribofuranosyl)pyridin-2-one-3-carboxylic acid, and their evaluation as anti-infective agents is described.