Synthesis and cytotoxic evaluation of some styryl ketones and related compounds

JR Dimmock, P Kumar, JW Quail, U Pugazhenthi…

Index: Dimmock, J.R.; Kumar, P.; Quail, J.W.; Pugazhenthi, U.; Yang, J.; et al. European Journal of Medicinal Chemistry, 1995 , vol. 30, # 3 p. 209 - 218

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Citation Number: 25

Abstract

A number of 1-aryl-4-methyl-1-penten-3-ones 1 were converted to the corresponding Mannich bases 2 and analogues 3. Attempts to form the azines 4 from several members in series 1 led to the isolation of the corresponding pyrazolines 5 or aryl aldehyde azines 6. Replacement of the isopropyl group of a compound in series 1 by methyl and ethyl functions led to ketones that reacted with hydrazine producing the corresponding azines. The ...