Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some 3-amino-and 3-methylbenzo [f] quinazolin-1 (2H)-ones

W Pendergast, JV Johnson, SH Dickerson…

Index: Journal of Medicinal Chemistry, , vol. 36, # 16 p. 2279 - 2291

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Citation Number: 51

Abstract

... We here describe the synthesis of a number of simple benzoquinazolines structurally related to 4a, some of which have potent inhibitory activity against human TS and 0 1993 American Chemical Society Page 2. 2280 Journal of Medicinal Chemistry, 1993, Vol. 36, No. ...