Organic & Biomolecular Chemistry 2006-03-21

5-Arylethynyl-2'-deoxyuridines, compounds active against HSV-1.

Mikhail V Skorobogatyi, Alexei V Ustinov, Irina A Stepanova, Anna A Pchelintseva, Anna L Petrunina, Valeriya L Andronova, Georgi A Galegov, Andrei D Malakhov, Vladimir A Korshun

Index: Org. Biomol. Chem. 4(6) , 1091-6, (2006)

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Abstract

Three new 5-arylethynyl-2'-deoxyuridines containing bulky aryls have been prepared and tested against HSV-1 in Vero cells. The introduction of a substituent in the phenyl group of an inactive compound, 5-phenylethynyl-2'-deoxyuridine, leads to the appearance of anti-HSV properties. The most active compounds are those containing a polycyclic aromatic hydrocarbon residue attached to the 5 position of 2'-deoxyuridine through a rigid triple bond.