Protection of a single-cysteine redox switch from oxidative destruction: on the functional role of sulfenyl amide formation in the redox-regulated enzyme PTP1B

S Sivaramakrishnan, AH Cummings…

Index: Sivaramakrishnan, Santhosh; Cummings, Andrea H.; Gates, Kent S. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 444 - 447

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Citation Number: 30

Abstract

Model reactions offer a chemical mechanism by which formation of a sulfenyl amide residue at the active site of the redox-regulated protein tyrosine phosphatase PTP1B protects the cysteine redox switch in this enzyme against irreversible oxidative destruction. The results suggest that 'overoxidation'of the sulfenyl amide redox switch to the sulfinyl amide in proteins is a chemically reversible event, because the sulfinyl amide can be easily ...