New potent and selective A 1 adenosine receptor agonists

SA Hutchinson, SP Baker, J Linden…

Index: Hutchinson, Sally A.; Baker, Stephen P.; Linden, Joel; Scammells, Peter J. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4877 - 4884

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Citation Number: 23

Abstract

... Bioorganic & Medicinal Chemistry. ... p < 0.02 and ∗∗ p < 0.007 compared ... 5″/H-6″), 3.79 (dd, 1H, H-5a′/H-5b′), 4.05 (dd, 1H, H-5a′/H-5b′), 4.12–4.14 (m, 1H, H-4′), 4.31 (t, 1H, H-3′), 4.64 (t, 1H, H-2′), 4.69–4.77 (br m, 1H, H-2″), 5.91 (d, 1H, H-1′), 8.17 (br s, 1H, H-8). 13 C NMR (CDCl 3 ): δ −5.5, −5.4, −5.0, −4.8, −4.7, −4.4, 17.9, 18.0, 18.5, 25.7, 25.8, 26.0, 33.1, 35.8, 37.3, 38.0, 41.1, 53.1, 62.1, 71.3, 75.6, 85.1, 88.8, 118.1, 138.7, 149.7 (J = 18.9 Hz ...