e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
SYNTHESIS OF α-HALOGENATED METHANEDIPHOSPHONATES1a, b
CE McKenna, LA Khawli, WY Ahmad…
Index: McKenna, Charles E.; Khawli, Leslie A.; Ahmad, Wan-Yaacob; Pham, Phuong; Bongartz, Jean-Pierre Phosphorus and Sulfur and the Related Elements, 1988 , vol. 37, p. 1 - 12
Abstract Methanediphospnonate (MDP) anions can exhibit anti-viral activity, inhibit bone resorption, and act as ligands in radiopharmaceuticals. α-Halo-substitution provides MDP derivatives (XYMDP, where×= H, F, CI or Br; Y= F, Cl or Br) with modified acid-base, steric and other properties. These compounds are conveniently made from the corresponding α- halogenated XYMDP esters (RO) 2P (O) CXYP (O)(OR) 2. Detailed procedures are given ...
[Nuretdinov, I. A.; Gubskaya, V. P.; Shishikina, N. I.; Fazleeva, G. M.; Berezhnaya, L. Sh.; Karaseva, I. P.; Sibgatullina, F. G.; Zverev, V. V. Russian Chemical Bulletin, 2002 , vol. 51, # 2 p. 337 - 341 Izvestiya Akademi Nauk, Seriya Khimicheskaya, 2002 , # 2 p. 317 - 320]
