Pyrrolo [1, 3] benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies

G Campiani, S Butini, S Gemma, V Nacci…

Index: Campiani; Nacci; Corelli; Anzini Synthetic Communications, 1991 , vol. 21, # 15-16 p. 1567 - 1576

Full Text: HTML

Citation Number: 30

Abstract

The prototypical dopamine and serotonin antagonist (±)-7-chloro-9-(4-methylpiperazin-1-yl)- 9, 10-dihydropyrrolo [2, 1-b][1, 3] benzothiazepine (5) was resolved into its R and S enantiomers via crystallization of the diastereomeric tartaric acid salts. Binding studies