Chemical Communications 2012-08-18

Discovery of a multi-bond forming, four-step tandem process: construction of drug-like polycyclic scaffolds.

Mark W Grafton, Louis J Farrugia, Hans Martin Senn, Andrew Sutherland

Index: Chem. Commun. (Camb.) 48(64) , 7994-6, (2012)

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Abstract

A one-pot tandem process involving an Overman rearrangement, ring closing enyne metathesis and a hydrogen bonding directed Diels-Alder reaction has been developed for the efficient diastereoselective synthesis of functionalised amino substituted tetralin and indene ring systems.