Synlett

Synthesis of novel 2-cyano-7-deaza-8-azapurine-and 2-cyano-8-azapurine-derived nucleosides

P Wainwright, A Maddaford, M Simms, N Forrest…

Index: Wainwright, Philip; Maddaford, Adrian; Simms, Michael; Forrest, Neil; Glen, Rebecca; Hart, James; Zhang, Xiurong; Pryde, David C.; Stephenson, Peter T.; Middleton, Donald S.; Guyot, Thierry; Sutton, Scott C. Synlett, 2011 , # 13 p. 1900 - 1904

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Abstract

Abstract A novel systematic approach to the synthesis of 2-cyano-7-deaza-8-azapurine derived nucleosides is described. It is shown how this chemistry was developed with the labile 2-substituted nitrile position in mind, and also how the same approach is applicable to 2-cyano-8-azapurine derived nucleosides.