Journal of Biomolecular Structure and Dynamics 1989-10-01

Role of the environment in the interaction of nonintercalators with Z-DNA.

K E Rao, N Ramesh, D Choudhury, S K Brahmachari, V Sasisekharan

Index: J. Biomol. Struct. Dyn. 7(2) , 335-45, (1989)

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Abstract

Interaction of the DNA binding nonintercalators Netropsin, Distamycin and the mPD derivative with Z-DNA has been studied. It has been found that environmental factors like the solvent and added cations significantly modulate the interaction of these ligands with Z-DNA. However no definite Z to B transition in presence of these ligands was found in any case, in contrast to previously reported results (Ch. Zimmer, C. Marck and W. Guschlbauer, FEBS Lett. 154, 156-160 (1983)).