Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II

…, VS Keerthi, KN Rajasekharan, RV Omkumar

Index: Mayadevi, M.; Omkumar, R. V.; Sherin, D. R.; Keerthi, V. S.; Rajasekharan, K. N. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 20 p. 6040 - 6047,8

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Citation Number: 22

Abstract

Calcium/calmodulin dependent protein kinase II (CaMKII) is involved in the mechanisms underlying higher order brain functions such as learning and memory. CaMKII participates in pathological glutamate signaling also, since it is activated by calcium influx through the N- methyl-d-aspartate type glutamate receptor (NMDAR). In our attempt to identify phytomodulators of CaMKII, we observed that curcumin, a constituent of turmeric and its ...