Toxicology in Vitro 2011-12-01

Octyl and dodecyl gallates induce oxidative stress and apoptosis in a melanoma cell line

Clarissa A.S. de Cordova, Claudriana Locatelli, Laura S. Assunção, Bruno Mattei, Alessandra Mascarello, Evelyn Winter, Ricardo J. Nunes, Rosendo A. Yunes, Tânia B. Creczynski-Pasa

Index: Toxicol. In Vitro 25(8) , 2025-34, (2011)

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Abstract

Highlights ► Octyl and dodecyl gallates were cytotoxic to B16F10 cells in a time dependent manner. ► Octyl and dodecyl gallates activated the caspase-3. ► Octyl and dodecyl gallates disrupted the mitochondrial potential. ► Octyl and dodecyl gallates increased the Bax and decreased Bcl-2 proteins expression. ► Octyl and dodecyl gallates induced an oxidative stress in B16F10 cells.