Bioorganic & Medicinal Chemistry Letters 2002-08-05

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.

Richard L Mackman, Hon C Hui, J Guy Breitenbucher, Bradley A Katz, Christine Luong, Arnold Martelli, Danny McGee, Kesavan Radika, Martin Sendzik, Jeffrey R Spencer, Paul A Sprengeler, James Tario, Erik Verner, Jing Wang

Index: Bioorg. Med. Chem. Lett. 12(15) , 2019-22, (2002)

Full Text: HTML

Abstract

The development of potent and selective urokinase-type plasminogen activator (uPA) inhibitors based on the lead molecule 2-(2-hydroxy-3-ethoxyphenyl)-1H-benzimidazole-5-carboxamidine (3a) is described.