Il Farmaco

Synthesis of 5-(2-, 3-and 4-methoxyphenyl)-4H-1, 2, 4-triazole-3-thiol derivatives exhibiting anti-inflammatory activity

L Labanauskas, E Udrenaite, P Gaidelis, A Brukštus

Index: Labanauskas; Udrenaite; Gaidelis; Brukstus Farmaco, 2004 , vol. 59, # 4 p. 255 - 259

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Citation Number: 148

Abstract

New S-alkylated 5-(2-, 3-and 4-methoxyphenyl)-4H-1, 2, 4-triazole-3-thiols (5a–c, 6a–c) and 5-(2-, 3-and 4-methoxyphenyl)-4-phenyl-4H-1, 2, 4-triazole-3-thiols (7a–c, 8a–c, 9a–c) were synthesized by the alkylation of 3-(2-, 3-and 4-methoxyphenyl)-4, 5-dihydro-1H-1, 2, 4- triazole-5-thiones (3a–c) or 3-(2-, 3-and 4-methoxyphenyl)-4-phenyl-4, 5-dihydro-1H-1, 2, 4- triazole-5-thiones (4a–c) with 1-iodobutane or 1-(1, 3-benzodioxol-5-yl)-2-bromo-1- ...