Biochemical and Biophysical Research Communications 2010-01-01

N-terminal segment of proinsulin C-peptide active in insulin interaction/desaggregation

Charlotte Nerelius, Gunvor Alvelius, Hans Jörnvall, Charlotte Nerelius, Gunvor Alvelius, Hans Jörnvall

Index: Biochem. Biophys. Res. Commun. 403 , 462-467, (2010)

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Abstract

Research highlights ► C-peptide fragment interactions with insulin involve the N-terminal part with Glu11. ► Insulin-interacting and membrane-interacting segments of C-peptide are different. ► Oligomerization of C-peptide involves yet different and additional segments. ► Oligomeric insulin is likely the form binding C-peptide.