Phytotherapy Research 2009-11-01

Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus.

M Ahmed Mesaik, Shahnaz Murad, Khalid Mohammed Khan, Rasool Bakhsh Tareen, Aqeel Ahmed, Muhammad Iqbal Choudhary

Index: Phytother Res. 23(11) , 1516-20, (2009)

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Abstract

Casticin (1), a flavonoid isolated from the aerial parts of Vitex agnus-castus, was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested in vitro for chemiluminescence, chemotaxis, T-cell proliferation and cytotoxicity. Casticin (1) exhibited a significant inhibitory effect on monocyte oxidative burst in a dose dependent manner. It was found to have a significant suppressive effect on the chemotaxic action at higher concentrations on fMLP (10(-8) m) stimulated neutrophils. It also showed a potent suppressive effect on PHA stimulated T-cell (PMBC).