Journal of the American Chemical Society 2002-05-22

The catalytic asymmetric Mannich-type reactions in aqueous media.

Shū Kobayashi, Tomoaki Hamada, Kei Manabe

Index: J. Am. Chem. Soc. 124(20) , 5640-1, (2002)

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Abstract

The catalytic, diastereo- and enantioselective Mannich-type reaction of a hydrazono ester with silyl enol ethers in aqueous media has been successfully achieved with ZnF(2), a chiral diamine ligand, and trifluoromethanesulfonic acid.