Ruthenium Pincer??Catalyzed Acylation of Alcohols Using Esters with Liberation of Hydrogen under Neutral Conditions

B Gnanaprakasam, Y Ben??David…

Index: Gnanaprakasam, Boopathy; Ben-David, Yehoshoa; Milstein, David Advanced Synthesis and Catalysis, 2010 , vol. 352, # 18 p. 3169 - 3173

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Citation Number: 49

Abstract

Abstract Acylation of secondary alcohols using non-activated esters, in particular symmetrical esters (such as ethyl acetate), is achieved under neutral conditions with the liberation of molecular hydrogen. This unprecedented, environmentally benign reaction is homogenously catalyzed by a dearomatized ruthenium pincer PNN complex.

~87%

~91%

~48%

~68%

~92%

~92%

~41%

~0%

~84%

~74%

Ruthenium Pincer??Catalyzed Cross??Dehydrogenative Coupling ...

[Srimani, Dipankar; Balaraman, Ekambaram; Gnanaprakasam, Boopathy; Ben-David, Yehoshoa; Milstein, David Advanced Synthesis and Catalysis, 2012 , vol. 354, # 13 p. 2403 - 2406]