Biochemical and Biophysical Research Communications 2013-11-01

Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives

Syo Nakajima, Koichi Watashi, Shinji Kamisuki, Senko Tsukuda, Kenji Takemoto, Mami Matsuda, Ryosuke Suzuki, Hideki Aizaki, Fumio Sugawara, Takaji Wakita

Index: Biochem. Biophys. Res. Commun. 440(4) , 515-20, (2013)

Full Text: HTML

Abstract

• Chemical screening identified sulochrin as a natural product reducing HCV infection. • Sulochrin inhibited HCV entry. • The anti-HCV activity of sulochrin was conserved in different HCV genotypes. • Cotreatment of sulochrin with IFNα or telaprevir showed a synergistic anti-HCV effect. • Derivative analysis identified the structure important for anti-HCV activity.