Bioorganic & Medicinal Chemistry Letters 2008-06-15

Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.

Suresh K Tipparaju, Sipak Joyasawal, Sara Forrester, Debbie C Mulhearn, Scott Pegan, Michael E Johnson, Andrew D Mesecar, Alan P Kozikowski

Index: Bioorg. Med. Chem. Lett. 18 , 3565-9, (2008)

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Abstract

Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.