Chemical Communications 2007-07-19

Alkylation of active methylene compounds with alcohols catalyzed by an iridium complex.

Masao Morita, Yasushi Obora, Yasutaka Ishii

Index: Chem. Commun. (Camb.) , 2850, (2007)

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Abstract

Base-free catalytic alpha-alkylation of active methylene compounds with primary alcohols was successfully achieved using an [IrCl(cod)](2) complex in the presence of PPh(3) to afford the corresponding saturated alpha-alkylated products in good yields.