Synthesis and anticonvulsant activity of some 7-alkoxy-2H-1, 4-benzothiazin-3 (4H)-ones and 7-alkoxy-4H-[1, 2, 4] triazolo [4, 3-d] benzo [b][1, 4] thiazines

LQ Zhang, LP Guan, CX Wei, XQ Deng…

Index: Zhang, Li-Qiu; Guan, Li-Ping; Wei, Cheng-Xi; Deng, Xian-Qing; Quan, Zhe-Shan Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 3 p. 326 - 331

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Citation Number: 29

Abstract

A series of 7-alkoxy-2H-1, 4-benzothiazin-3 (4H)-ones and a new series of 7-alkoxy-4H-[1, 2, 4] triazolo [4, 3-d] benzo [b][1, 4] thiazine derivatives were synthesized using 5- methoxybenzo [d] thiazol-2-amine as starting material. The structures of the compounds were elucidated by IR, 1 H-NMR spectroscopic data and microanalyses. The anticonvulsant activity of these compounds was evaluated by maximal electroshock (MES) test and ...