[(Arylcarbonyl) oxy] propanolamines. 1. Novel. beta.-blockers with ultrashort duration of action

…, KX Mai, C Barcelon-Yang, RJ Borgman…

Index: Kam, Sheung-Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1007 - 1016

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Citation Number: 25

Abstract

Novel [(arylcarbonyl) oxy] propanolamines were synthesized and investigated as potential ultrashort-acting/3-adrenergic receptor blockers. Many of these analogues exhibited good potency and short duration. The N-ureidoalkyl analogue 85 (ACC-9089) has a potency equal to propranolol and a duration of action of about 21 min in the dog. It has been selected as a candidate for further clinical study. Structureactivity relationships and structure- ...