Journal of Organic Chemistry 2004-01-23

Facile preparation of beta-fluoro amines by the reaction of aziridines with potassium fluoride dihydrate in the presence of Bu4NHSO4.

Ren-Hua Fan, Yong-Gui Zhou, Wan-Xuan Zhang, Xue-Long Hou, Li-Xin Dai

Index: J. Org. Chem. 69(2) , 335-8, (2004)

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Abstract

Potassium fluoride combined with tetrabutylammonium bisulfate is an efficient reagent to convert a variety of aziridines derived from cyclic and acyclic alkenes to beta-fluoro amine derivatives in high yield.