Tumori 1990-06-30

Improvement of radioactive colloid binding by tumor cells.

L J Anghileri, C Marchal, P Maincent, J Robert

Index: Tumori 76 , 217-219, (1990)

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Abstract

Treatment of P388 leukemia cells with poly-DL-lysine (Poly-lys) considerably increases the binding of colloidal chromic phosphate (32P). This augmentation of the number of particles that are bound is in direct relationship with Poly-lys concentration, and very significantly with its degree of polymerization. Treatment with Poly-lys molecular weight 77,000 shows a 100% increase of binding with 200 micrograms and of 50% with 100 micrograms. Poly-lys M.W. 8,000 presents no significant increase, and for the other molecular weights the binding is intermediate.