Analytical chemistry

Predicting drug-membrane interactions by HPLC: structural requirements of chromatographic surfaces

H Liu, S Ong, L Glunz, C Pidgeon

Index: Liu, Hanlan; Ong, Shaowei; Glunz, Louis; Pidgeon, Charles Analytical Chemistry, 1995 , vol. 67, # 19 p. 3550 - 3557

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Citation Number: 72

Abstract

Drug-membrane interactions have recently been studied by immobilized artificial membrane (IAM) chromatography (Pidgeon, C.; et al. J. Med. Chem. 1995, 38,590-595. Ong, S.; et al. Anal. Chem. 1995, 67,755-762), and the molecular recognition properties of IAM surfaces toward drug bindhg/partitioning appear to be remarkably close to the molecular recognition properties of fluid membranes. The structural requirements of chromatography surfaces to ...