IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo [1, 2-a] pyridine binding

…, AP Higueruelo, K Jenkins, SR Mack, T Morgan…

Index: Buckley, George M.; Ceska, Thomas A.; Fraser, Joanne L.; Gowers, Lewis; Groom, Colin R.; Higueruelo, Alicia Perez; Jenkins, Kerry; Mack, Stephen R.; Morgan, Trevor; Parry, David M.; Pitt, William R.; Rausch, Oliver; Richard, Marianna D.; Sabin, Verity Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3291 - 3295

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Citation Number: 44

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Dedicated to the memory of our friend and colleague David Rainey. ... A potent IRAK-4 inhibitor was identified through routine project cross screening. The binding mode was inferred using a combination of in silico docking into an IRAK-4 homology model, surrogate crystal structure analysis ...