Molecules

Eco-friendly synthesis and antiproliferative evaluation of some oxygen substituted diaryl ketones

…, J Benites, GG Muccioli, PB Calderon, JA Valderrama

Index: Arenas, Paola; Pena, Andres; Rios, David; Benites, Julio; Muccioli, Giulio G.; Calderon, Pedro Buc; Valderrama, Jaime A. Molecules, 2013 , vol. 18, # 8 p. 9818 - 9832

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Citation Number: 7

Abstract

Abstract: A broad variety of oxygen-substituted diaryl ketones has been synthesized by solar energy-induced Friedel Crafts acylations of 1, 4-benzo-and 1, 4-naphthoquinones with benzaldehydes. The in vitro antiproliferative properties of the photoproducts were assessed on prostate (DU-145), bladder (T24) and breast (MCF7) human-derived tumor cell lines and compared to non-tumor mouse fibroblasts (Balb/3T3). Among the tested compounds, it ...