Carbohydrate Research 2010-09-23

Regioselective facile one-pot Friedländer synthesis of sugar-based heterocyclic biomolecules.

Subbiah Nagarajan, Pandian Arjun, Nanjian Raaman, Thangamuthu Mohan Das

Index: Carbohydr. Res. 345(14) , 1988-97, (2010)

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Abstract

Regioselective facile one-pot synthesis of 16 different sugar-based quinoline, naphthyridine, and xanthone derivatives is reported. The compounds are characterized by NMR spectroscopy and elemental analysis. The beta-Anomeric form of the sugar moiety was identified from (1)H NMR studies. Antimicrobial studies of these sugar-heterocyclic derivatives, 3a, 3b, 3f, 5c, 7a, 7b, and 7c show excellent activity against different microbes.Copyright 2010 Elsevier Ltd. All rights reserved.